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Copyright 1999 The Omaha World-Herald Company  
Omaha World-Herald

May 24, 1999, Monday SUNRISE EDITION

SECTION: ;NEWS; Pg. 1

LENGTH: 3001 words

HEADLINE: Today's High-Tech Harvest Farms and ranches at the end of the 20th century have evolved into high-tech businesses relying as much on computers and biogenetics as the machinery turning the soil Agricultural Milestones A Century of Agricultural Evolution Glossary

BYLINE: BILL HORD

SOURCE: WORLD-HERALD BUREAU

DATELINE: Lincoln

BODY:
Barbara is a good mother.

Her offspring go on to big things. They provide consistently good-quality beef and are good milkers. One of her calves even rose to stardom as a grand champion bull.

All the better, then, for owners Chuck and Linda Pohlman that through the wonders of biotechnology Barbara has had 32 calves - only seven of which she gave birth to nature's way. She also has 36 grandsons and granddaughters.

The transfer of embryos from Barbara (registered as Pohlman's Barbara 13487, a purebred Angus), to other surrogate mothers is an example of how technology is changing life on the farm and ranch.

To see the impact, American consumers have only to look at the diversity of products on supermarket shelves. And at their grocery bills, which now consume less of the average annual income than decades ago.

More change is coming, including such bio-tech wonders as cloning and the creation of plants and animals with qualities from multiple species.

The changes hold opportunity for farmers. But they aren't being universally welcomed. Some nations have rejected high-tech U.S. farm products. And some farmers fear they'll lose more control over their work and livelihoods.

"Even though life on the farm has seen a lot of changes in the last 100 years," Chuck Pohlman said, "the pace of change is picking up."

Biotechnology, the alteration of living organisms to make products, has its roots in biochemical discoveries early in the 20th century. It is overwhelming agriculture going into the 21st century.

"Biochemistry was the minor leagues, and biotechnology is the major leagues," said Bob Graybosch, a University of Nebraska-Lincoln geneticist.

The embryo work on Barbara is done on a farm north of Norfolk, where Chuck Pohlman grew up watching his father till with teams of horses.

It's where he once rode a cultivator to rid soybean rows of weeds. The old cultivator gathers dust now, because Roundup Ready beans are genetically engineered so they won't be damaged when spraying for weeds with Roundup herbicide.

"It kills everything except the soybean," Pohlman said.

Scientists aren't just moving embryos from animal to animal. They are splitting genes to ensure that the farm product - plant or animal - will be exactly what was intended. Like never before, a farmer can reap what he sows.

"I'm wondering what's going to happen in the future," said Ted Givens, director of research for NC+ Hybrids Co., a Lincoln seed-producing company owned by 15 farmers. "It's exciting, but also troublesome."

Now agriculture is at the forefront of one of the planet's most dramatic developments - the deciphering of the code of life and the creation of companies whose main purpose is to manipulate life.

The foundations for today's technology go back to Austrian monk Gregor Mendel, who discovered the principles of genetics in 1866.

By 1914, scientists had discovered that crossbred plants had more vitality, a phenomenon known as "hybrid vigor." Later, they learned that the same phenomenon occurred when animals were crossbred.

Yields for the No. 1 Midlands crop, corn, averaged about 25 bushels an acre in the first three decades of the century, including the Dust Bowl days of the'30s.

They began to soar with the help of seed hybrids, pesticides and herbicides.

Hybrid corn was introduced in Iowa in 1928. By the early 1940s, it was planted on virtually all corn acres in the state. The hybrids allowed denser planting and were more resistant to insects. By 1950, the Corn Belt was all hybrids.

Average corn yields rose to 34 bushels in the'40s and 44 in the '50sto 120 in the'90s.

By crossbreeding the nearly 1,000 corn varieties that existed at the turn of the century, biologists created improved hybrid plants. Wheat varieties were bred to create semi-dwarf wheat, which was shorter than earlier popular varieties and would stand sturdy even when invigorated with fertilizer and irrigation.

But for all its benefits, crossbreeding of plants and animals was only the beginning of where technology would take agriculture in the 20th century.

Manipulation of genes in the laboratory changed the rules in the soil and on the ranch.

Instead of spraying weeds and insects, crops can be their own little soldiers, killing what attacks them. Already, Bt corn will react with ingredients in the soil to slay a corn borer.

Life-sciences companies like Novartis and Monsanto have created genetically altered crops that tolerate their own herbicides.

Other life-sciences companies have followed suit, luring farmers to shift acres from wheat, corn and other crops to beans.

"You change from weed-control treatments that weren't very effective to one that is almost 100 percent effective," said Peter Mascio, seed biotechnology manager for Cargill Inc.

Mascio said the impact of insect-resistant seeds, the Bt varieties, is staggering.

Bt corn, which was planted to about 10 percent of corn acres in 1998, is expected to spread to 50 percent of the acres by next year, Mascio said.

The century also brought the first use of frozen semen and the transfer of embryos so that cows that can't match Barbara's qualities can now give birth to her calves.

The pork industry has benefited dramatically as it turns out one pork chop after another that is of the same quality as the one before.

Cattlemen in Nebraska's Sand Hills have long been breeding to improve quality. At the turn of the century, Texas longhorns still dominated the landscape and cattle were raised almost totally on grass.

Cattlemen began importing breeds from England, and for decades brown-and-white Herefords and Black Angus reigned supreme. The new breeds provided juicier steaks, especially when fattened on grain for half their lives.

In recent years, many cattlemen bred their Herefords with Angus to take advantage of traits of both animals. The result is a breed of white-faced "black baldies" now prevalent in the Sand Hills.

"There was a perception, because the Black Angus has marbled well, that it was a better animal," said Homer Buell, whose family has ranched near Bassett since 1883 and converted about half its herd to black baldy.

Then came the bigger breeds across the Atlantic, such as Charolais and Limousin from France, further improving the fattening efficiency of cattle producers. At the turn of the century, most cattle went to market at age 2 or 3. Now they go at 14 months.

Crossbreeding has brought diversity to Sand Hills herds, said Terry Klopfenstein, a professor of animal science at UNL, producing cattle more suited for the environment. But that diversity also has contributed to one of the beef industry's biggest problems - lack of consistency in meat.

Newer technology is trying to overcome that inconsistency by more precisely controlling the genetics - and therefore the traits - of each animal.

"As cloning matures over the next few years, production agriculture will have the technology to build herds that are designed for beef and milk production or for pharmaceuticals and reduce the variation in each herd," said Michael Bishop, a former Agriculture Department animal researcher at the University of Nebraska South Central Research and Extension Center at Clay Center.

Bishop now finds himself at the cutting edge of the cloning issue as vice president of Infigen Inc., a livestock genetics company in DeForest, Wis.

Through cloning, animals could become "biofactories" to replace large industry factories, Bishop said. "Animals can be maintained at a far cheaper price than a factory," he said.

Dairymen could select cows that produce milk yielding the best mozzarella cheese, then clone them for that purpose.

Entire herds of cattle or hogs could be bred to produce a medical product, such as transplant organs or antibiotics. Bishop said such transplants are likely to occur before 2010.

By inserting the gene of one organism into the DNA of another organism - creating "recombinant DNA" - scientists are able to create new forms of life. The genes from a cold-water fish can improve the frost-resistance of a tomato plant. The genes from a firefly can make the leaves of a tobacco plant glow.

"Those changes will forever change the lives of those involved in agriculture," said Sano Shimoda, a California investment broker for the biosciences industry.

Many people are like Givens, embracing the new technology but wondering how changes will play out on farms and ranches.

One question on the minds of many in agriculture is whether farmers will get their fair share of the value of new products. Will their lives be controlled by others as they take their place in the fast-developing agricultural industrial complexes?

Will they be like employees for the world conglomerates, paid a minimal amount to grow something to order? Or will they be like business executives who have negotiating power?

"The new system will not work unless value is shared among all the players in the value chain, including the farmer," Shimoda said.

Many farmers cringe at the idea that large companies hold patents on seed technology, prohibiting farmers from saving some of their seed to plant the following year.

Monsanto has developed technology, not yet in use, that will protect its own seed patents by inserting a "terminator" gene that would shut off the patented technology after one crop.

Shimoda said farmers will need to learn to compete in the new arena. They will need to shift their focus from "how" to raise crops or livestock to "what" to raise, a fundamental change of emphasis from the cost of production to the value of the end product.

A focus on the end product could provide the kinds of results experienced by the Pohlmans, who have reaped $ 215,000 in sales from Barbara's offspring in a decade.

"You would probably make a third as much" if the surrogate cows were having their own calves, Linda Pohlman said.

If you can do so with sons and daughters similar to Barbara, imagine exact replicas. Remember Dolly, cloned in 1997 as the identical twin of a sheep born several years earlier? The genetic information for Dolly was drawn by Scottish embryologist Ian Wilmut from one sheep into the emptied egg of another.

Improved traits through the splitting of genes are already a reality.

Farmers are growing high-oil corn, produced from seeds that have been genetically engineered to increase the feeding benefits to livestock.

The possibilities for specialty products seem endless.

Grocery shoppers are expected to find healthier cooking oils, grown from seeds genetically designed for that purpose.

The attention is going beyond improvements for feed and food. The health-care industry is almost certain to be a major customer of agriculture in the 21st century. So is the manufacturing industry.

A new motor oil made from soybeans, rather than petroleum, is being tested.

UNL researchers are trying to develop a corn plant to produce levulinic acid, which has potential uses in food, pharmaceuticals and industry, including as an antifreeze, a biodegradable plastic and fuel. Currently, the product comes from petroleum.

"Specifications" may one day be the key word in agriculture contracts. Customers will order certain food quality and safety. Like other industries, farmers would get paid for the quality of their product and the efficiency of production.

Skeptics of the fast-changing world of agriculture worry that the balance of nature could be tilted if genetically modified seeds cross-pollinate with other plants.

"I think we have to start with the idea that this is unlike anything we have every seen," said Jeremy Rifkin of Washington, a prolific author and opponent of the rush to biogenetics.

Rifkin has called for a worldwide moratorium against releasing genetically engineered food crops and other gene-spliced organisms into the environment.

No one knows, he said, how plants with genes to produce chemicals and drugs would affect nature if left to run amok among foraging animals, seed-eating birds and soil insects.

Organic farmers have expressed concern that cross-pollination of some genetically altered crops could unwittingly infect the "purity" of their fields.

Concerns about genetic manipulation have complicated trade negotiations both for livestock and grain.

The European Union, a big trading partner, is balking. It bans U.S. beef produced with hormones. Last week, it halted the approval process for a Bt corn after experiments revealed a high death rate among butterfly larva that were fed milkweed dusted with pollen from genetically altered corn.

"They perceive that their customers don't want the stuff," said UNL's Graybosch.

Even those who are racing forward with the technology agree that it has risks.

"Things are never risk-free," said Steve Baenziger, a UNL plant breeding specialist. "People need to ask if, in the history of science, we have generally done better or worse by accepting new technologies."

Agricultural Milestones

1900: Scientists revive the work of Austrian monk Gregor Mendel, who published a work on plant heredity in 1866.

1908: Henry Ford first designs the Model T to run on alcohol.

1928: Hybrid corn introduced.

1941: Corn hybrids grown on virtually all Iowa corn acres.

1953: James Watson, Francis Crick discover the structure of DNA.

1953: Frosty, the first living calf born to a cow impregnated from frozen semen in the United States, is born

Mid 1960s: Biochemists decipher the genetic code. DNA molecule is now understood to contain the genetic information for most life forms.

1970: Clean Air Act jump-starts the production of ethanol as a clean-burning fuel extender for gasoline.

1970s: Researchers perfect various methods for splicing foreign DNA into other organisms.

1973: Biologists recombine DNA from two unrelated organisms to form a new organism with traits of each.

1982: First commercial application of genetic engineering ? human insulin for diabetes treatment, eventually to almost totally replace insulin from livestock glands.

1983: First transgenic plant, a tobacco plant resistant to an antibiotic.

1984: Calf named Lattin born to a cow impregnated from semen that had been frozen 30 years.

1988: Work begins on the Human Genome Project, a worldwide effort to map and sequence the 80,000-100,000 human genes, to be completed in 2005. 1994: First commercialization of a transgenic plant in the United States ? a delayed-ripening tomato.

1995: Corn that produces its own insecticide is developed by inserting a gene from Bacillus thuringiensis (Bt), a natural pesticide.

1996: Grace is born, a transgenic goat producing an antibody to fight cancer.

1996: First gene-spliced food crops are planted; the European Union approves importing pesticide-resistant soybeans.

1996: Major seed companies introduce Bt corn.

1997: Scottish embryologist Ian Wilmut announces birth of Dolly, a sheep that is the worlds first clone.

1998: About 25.7 million acres planted with Roundup Ready soybean and corn seed, genetically altered to withstand the chemicals used to kill weeds.

Glossary

Bt corn: A genetically produced variety that interracts with soil bacterium (bacillus thuringiensis) to kill European corn borers.

Biotechnology: The application of living organisms to develop new products.

Double helix: The physical structure of DNA, consisting of two parallel strands of DNA coiled together.

DNA: Deoxyribonucleic acid, which transfers genetic information from one generation to the next.

Gene: A portion of a chromosome that contains the hereditary information necessary for the production of a protein.

Genetic Engineering: The technique of removing, modifying or adding genes to a living organism. Also called gene splicing, recombinant DNA (rDNA) technology or genetic modification.

Herbicide: A substance used to kill plants, especially weeds.

High-oil corn: Corn hybrid that has superior feeding value in both poultry and swine and holds promise for food and industrial applications.

Insecticide: A chemical agent used to kill insect pests.

Hybrid: A plant resulting from a cross between parents that are related but not genetically identical.

Recombinant DNA (rDNA): Modified DNA produced by removing, modifying or adding genes to create new DNA.

A Century of Agricultural Evolution

Pork

Through the late 1940s, pork producers obliged consumers who wanted lard for cooking by raising relatively fat hogs. Pork provided the basis for soldiers rations, and pork fat went into making nitroglycerine for explosives. After World War II, people began thinking more about health and diet, so producers concentrated on developing a leaner hog. Today, improved genetics and better feeding practices have resulted in a market hog 50 percent leaner than in the late 1960s.

Beef

The beef industry has evolved from the stately Texas longhorn, fed almost totally on grass, to a variety of breeds that spend half their lives eating grain. The result is a more tender steak and a more efficient industry. The early part of the century brought shorthorns, Herefords and Angus across the Atlantic. In mid-century, breeds like Charolais and Limousin from France, known for their size, were introduced.

Corn

Leaves on corn plants until about the 1960s were nearly horizontal to the stalk with a slightly downturned tip. Leaves on modern corn are stiff and stick up at a farily high angle. Kernels on modern dent corn, the majority of the corn grown in the United States, are smoother. Smooth kernels dont splinter as badly in combines. Modern hybrids stay greener in the field longer into the fall, aiding kernel development. Older varieties typically suffered premature death.



GRAPHIC: Color Photos/2 MICROCHIP: Computer chips in the ears of cattle may one day allow producers to track the effectiveness of feeds, medicines and genetic combinations. Ryan Urkoski, a student at Northeast Community College in Norfolk, Neb., places a microchip in a heifer's ear. CHAMPION MOM: The good hereditary qualities of Barbara, a purebred Angus, are transfered via embryos to other cows. Chuck and Linda Pohlman, who farm near Norfolk, own Barbara. B&W Photos/7 TINY TECHNOLOGY: Microchips as small as a fingertip can yield volumes of information about cattle. The chips, implanted in the animals' ears through a syringe, allow monitoring of animals as they move from the feedlot to the slaughterhouse.; Bill Batson/World-Herald/2sf /2 Jeff Bundy/World-Herald/1 Jeff Beiermann/World-Herald/1 Phil Johnson/World-Herald/1

LOAD-DATE: December 10, 1999




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