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Copyright 2000 Globe Newspaper Company  
The Boston Globe

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May 12, 2000, Friday ,THIRD EDITION

SECTION: NATIONAL/FOREIGN; Pg. A1

LENGTH: 1023 words

HEADLINE: Globe UN correspondent Joe Lauria contributed to this report from New York.;
AIDS DRUG PRICES CUT FOR AFRICA PHARMACEUTICAL COMPANIES YIELD TO PRESSURE FROM WHITE HOUSE

BYLINE: By Kurt Shillinger, Globe Correspondent

BODY:
JOHANNESBURG - Under increasing pressure from the Clinton administration and African leaders, five of the world's largest pharmaceutical companies yesterday announced that they would make their AIDS drugs affordable for tens of millions of people across the southern hemisphere.

Unveiling the joint agreement, the United Nations in Geneva said the companies would slash the price of their AIDS drugs by as much as 90 percent of what Americans pay.   Health officials in South Africa, struggling to cope with one of the highest rates of HIV infection in the world, reacted with cautious optimism to the announcement.

"I would welcome anything that brings the price of these drugs down, but I would like to see more details of their offer," said James McIntyre, the chief AIDS researcher and medical doctor at Bharagwanath Hospital in Soweto, the sprawling township south of Johannesburg. "If the companies are just doing this to protect their intellectual property rights, it will be a waste of time."

The announcement could mark the beginning of a rapprochement between the drug firms and African governments long embittered by what they saw as efforts by powerful Western multinationals to exploit Africa's epidemic for profit.

About 23 million people south of the Sahara Desert have the human immunodeficiency virus, according to the United Nations, and AIDS kills more than 2 million Africans annually. At current prices, anti retroviral treatments are prohibitively expensive for even the best African budgets.

But even with lower costs, regional experts said, much more was needed before the drugs could be made widely available in poorer countries that lack the expertise and infrastructure to administer complicated treatment regimens.

"We need significant new funding that is on a level with the enormous human, social, and economic challenges now being imposed by the epidemic," said Peter Piot, executive director of UNAIDS, the joint UN program responding to the epidemic globally. "Lowering the prices of medicines, however, is only one critical factor in what must become a much broader and more urgent effort."

The five pharmaceutical companies announcing the price cuts were Glaxo Wellcome of Britain, Bristol-Myers Squibb of New York, Boehringer Ingelheim of Germany, the Swiss firm Roche, and Merck and Co. of New Jersey.

Glaxo, which manufactures the joint treatment of AZT and 3TC called Combivir, said it would reduce the price of the daily regimen from $16.50, the cost in the United States, to $2 in developing countries. Ugandans currently pay about $6 per day for the treatment. AZT, international studies show, can reduce the risk of infection from pregnant woman to fetus by as much as 50 percent.

Devising a plan

The deal, which follows an urgent appeal by UN Secretary General Kofi Annan last December, involves the World Health Organization, the World Bank, the UN Children's Fund, and the UN Population Fund. The next step, according to officials from these agencies, is to work out a plan for how the drugs will be purchased, distributed, and administered. That plan will be announced in July at the international conference on AIDS in Durban, South Africa.

One scenario, according to Christopher Lovelace, director of health, nutrition, and population at the World Bank in Washington, D.C., is for his organization to offer low-maintenance loans to African countries. UNICEF would then purchase the drugs from the companies.

WHO might be involved in training health officials how to administer the drugs, which can be dangerous or rendered ineffective if not taken correctly.

"If a country wishes to take advantage of these reduced prices, the bank would certainly consider supporting those countries," Lovelace said. "It is hard for us to imagine a situation where there was a well-conceived national strategy, a government request to borrow, and we wouldn't support it."

Lovelace said a country with a per capita income of less than $1,000 might receive no-interest loans.

With as much as 25 percent of their adult populations infected with HIV, African countries have been struggling for years to find affordable responses to the AIDS epidemic. Despite some recent concessions - Bristol-Myers Squibb last year announced that it would donate $100 million over five years to help African countries combat AIDS - the pharmaceutical companies have not responded willingly to demands for lower prices.

US issues executive order

On Wednesday, President Clinton issued an executive order relaxing US protection of intellectual property rights held by drug companies, thereby allowing African governments more leeway in obtaining cheaper generic alternatives to the name-brand drugs. Congress earlier rejected an almost identical provision from an African trade bill, which pharmaceutical companies had fought strongly against. Annan applauded Clinton's decision.

"There has been a controversy for some time as to whether or not African countries who have the capacity to produce locally generic versions of some of these drugs at a much cheaper cost will be allowed to do that," he said. "I think the executive order is an important step in the fight against AIDS . . . on two fronts: prevention and treatment."

The battle for cheaper drugs has angered African governments - none more than South Africa. Even at $2 per day, anti retroviral treatments would be too costly for most individual Africans to pay, AIDS specialists say, leaving the burden on state budgets. The lower costs could, however, finally make antiretroviral treatment cheaper than hospitalization.

But without knowing the fine-print details of the new offer, South African health officials remain wary.

"Even if the pharmaceuticals say they will reduce the cost, before we can say yes, we must study the terms of the offer," said Confidence Moloko, chairman of the national health committee of the ruling African National Congress.

"We have to know what we're getting into. We can't get these treatments at lower costs for three or four months, and then find out we've been suckered."

LOAD-DATE: May 12, 2000




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