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May 12, 2000, Friday ,THIRD EDITION 
SECTION: NATIONAL/FOREIGN; Pg. A1 
LENGTH: 1023 words 
HEADLINE: 
Globe UN correspondent Joe Lauria contributed to this report from New York.; 
AIDS DRUG PRICES CUT FOR AFRICA 
PHARMACEUTICAL COMPANIES YIELD TO PRESSURE FROM WHITE HOUSE 
BYLINE: By Kurt Shillinger, Globe Correspondent 
BODY: 
JOHANNESBURG - Under increasing pressure from 
the Clinton administration and African leaders, five of the world's largest 
pharmaceutical companies yesterday announced that they would make their 
AIDS drugs affordable for tens of millions of people across the 
southern hemisphere. 
Unveiling the joint agreement, the United Nations 
in Geneva said the companies would slash the price of their 
AIDS drugs by as much as 90 percent of what Americans 
pay.   Health officials in South Africa, 
struggling to cope with one of the highest rates of HIV infection in the world, 
reacted with cautious optimism to the announcement. 
"I would welcome 
anything that brings the price of these drugs down, but I would like to see more 
details of their offer," said James McIntyre, the chief AIDS 
researcher and medical doctor at Bharagwanath Hospital in Soweto, the sprawling 
township south of Johannesburg. "If the companies are just doing this to protect 
their intellectual property rights, it will be a waste of 
time." 
The announcement could mark the beginning of a rapprochement 
between the drug firms and African governments long embittered by what they saw 
as efforts by powerful Western multinationals to exploit 
Africa's epidemic for profit. 
About 23 million people 
south of the Sahara Desert have the human immunodeficiency virus, according to 
the United Nations, and AIDS kills more than 2 million Africans 
annually. At current prices, anti retroviral treatments are prohibitively 
expensive for even the best African budgets. 
But even with lower costs, 
regional experts said, much more was needed before the drugs could be made 
widely available in poorer countries that lack the expertise and infrastructure 
to administer complicated treatment regimens. 
"We need significant new 
funding that is on a level with the enormous human, social, and economic 
challenges now being imposed by the epidemic," said Peter Piot, executive 
director of UNAIDS, the joint UN program responding to the epidemic globally. 
"Lowering the prices of medicines, however, is only one critical factor in what 
must become a much broader and more urgent effort." 
The five 
pharmaceutical companies announcing the price cuts were Glaxo Wellcome of 
Britain, Bristol-Myers Squibb of New York, Boehringer Ingelheim of Germany, the 
Swiss firm Roche, and Merck and Co. of New Jersey. 
Glaxo, which 
manufactures the joint treatment of AZT and 3TC called Combivir, said it would 
reduce the price of the daily regimen from $16.50, the cost in 
the United States, to $2 in developing countries. Ugandans 
currently pay about $6 per day for the treatment. AZT, 
international studies show, can reduce the risk of infection from pregnant woman 
to fetus by as much as 50 percent. 
Devising a plan 
The deal, 
which follows an urgent appeal by UN Secretary General Kofi Annan last December, 
involves the World Health Organization, the World Bank, the UN Children's Fund, 
and the UN Population Fund. The next step, according to officials from these 
agencies, is to work out a plan for how the drugs will be purchased, 
distributed, and administered. That plan will be announced in July at the 
international conference on AIDS in Durban, South 
Africa. 
One scenario, according to Christopher 
Lovelace, director of health, nutrition, and population at the World Bank in 
Washington, D.C., is for his organization to offer low-maintenance loans to 
African countries. UNICEF would then purchase the drugs from the companies. 
WHO might be involved in training health officials how to administer the 
drugs, which can be dangerous or rendered ineffective if not taken correctly. 
"If a country wishes to take advantage of these reduced prices, the bank 
would certainly consider supporting those countries," Lovelace said. "It is hard 
for us to imagine a situation where there was a well-conceived national 
strategy, a government request to borrow, and we wouldn't support it." 
Lovelace said a country with a per capita income of less than 
$1,000 might receive no-interest loans. 
With as much as 
25 percent of their adult populations infected with HIV, African countries have 
been struggling for years to find affordable responses to the 
AIDS epidemic. Despite some recent concessions - Bristol-Myers 
Squibb last year announced that it would donate $100 million 
over five years to help African countries combat AIDS - the 
pharmaceutical companies have not responded willingly to demands for lower 
prices. 
US issues executive order 
On Wednesday, President 
Clinton issued an executive order relaxing US protection of intellectual 
property rights held by drug companies, thereby allowing African 
governments more leeway in obtaining cheaper generic alternatives to the 
name-brand drugs. Congress earlier rejected an almost identical provision from 
an African trade bill, which pharmaceutical companies had fought strongly 
against. Annan applauded Clinton's decision. 
"There has been a 
controversy for some time as to whether or not African countries who have the 
capacity to produce locally generic versions of some of these drugs at a much 
cheaper cost will be allowed to do that," he said. "I think the executive order 
is an important step in the fight against AIDS . . . on two 
fronts: prevention and treatment." 
The battle for cheaper drugs has 
angered African governments - none more than South Africa. Even 
at $2 per day, anti retroviral treatments would be too costly 
for most individual Africans to pay, AIDS specialists say, 
leaving the burden on state budgets. The lower costs could, however, finally 
make antiretroviral treatment cheaper than hospitalization. 
But without 
knowing the fine-print details of the new offer, South African health officials 
remain wary. 
"Even if the pharmaceuticals say they will reduce the cost, 
before we can say yes, we must study the terms of the offer," said Confidence 
Moloko, chairman of the national health committee of the ruling African National 
Congress. 
"We have to know what we're getting into. We can't get these 
treatments at lower costs for three or four months, and then find out we've been 
suckered." 
LOAD-DATE: May 12, 2000