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Copyright 2001 The Atlanta Constitution  
The Atlanta Journal and Constitution

August 8, 2001 Wednesday, Home Edition

SECTION: News; Pg. 3A

LENGTH: 691 words

HEADLINE: Scientists in battle over human cloning

BYLINE: HERVEY PEAN

SOURCE: AJC

BODY:
Washington --- Three scientists announced at a contentious conference Tuesday that they are prepared to start cloning 200 humans as early as November.

"Infertility is a disability, and with this technology we can safely and efficiently help couples who want to reproduce," Panos Zavos, a Kentucky-based doctor, said during a meeting at the National Academy of Sciences.

Zavos and Italian doctor Severino Antinori said they would use techniques similar to those used to clone animals.

Under the glare of television lights, the researchers had to defend their plans against the claims of 28 other international scientists who say human cloning is not safe.

Ian Wilmut, the scientist who created Dolly, a cloned sheep, said human cloning is a "disconcerting concept." Wilmut said cloning is inefficient and too full of errors to be done on humans; he said it took some 277 tries to create Dolly.

"We can expect late abortions, dead children and surviving but abnormal children," Wilmut said during the conference.

Rudolf Jaenisch, a biologist at the Massachusetts Institute of Technology and pioneer in animal cloning, agreed.

"This is not acceptable; this is not responsible," Jaenisch told the group of cloning advocates. "There is no way to predict whether a given clone will develop into a normal or abnormal individual."

The panel is gathering information on the scientific and ethical issues surrounding human cloning for a report on whether the United States should impose a moratorium on the practice. The Academy's Committee of Science, Engineering and Public Policy will issue the report in September.

In the cloning process, the genes of a cell are implanted into a human egg from which all the genetic material has been removed. The egg, which is then cultured into an embryo, is implanted in the mother's womb. The offspring would have the same gene makeup as the cell donor.

Brigitte Boisselier, director of Clonaid, the first human cloning company, said she is prepared, immediately, to clone babies for infertile couples. Boisselier would not say what methods she plans to use or what the results of Clonaid's previous cloning attempts have been.

"There are huge demands for this, and these people need to be considered," Boisselier said. "I do believe that it's a fundamental right to reproduce the way you want. If you want to reproduce by mixing your genes with someone else's, you have the right. If you want to reproduce yourself by cloning your genes, you have the right."

Both Zavos and Antinori attacked anti-cloning legislation that was passed in the House last week. The cloning ban would impose fines of $1 million or more and as many as 10 years in prison for violators. The Senate has not yet considered the legislation.

President Bush supports the ban on cloning and called the House action "a strong ethical statement."

The Food and Drug Administration has prohibited human cloning in the United States.

Zavos said the cloning experiment would take place in an undisclosed location outside of the United States. He also expressed dismay at the "attitude" of the public and Congress toward human cloning.

"They're afraid, they're scared, and they're misinformed," said Zavos, who is the director of the Andrology Institute. "If the politicians are going to behave the way they do, they will force this technology into clandestine labs."

Zavos and Antinori said they let their patients know that cloning is dangerous and that their offspring might die or be born with abnormalities.

"These are some of the possible problems, but they are the same problems with in-vitro fertilization," Zavos said. In-vitro fertilization is an assisted reproduction technique in which fertilization is accomplished outside of the body.

Zavos and Antinori said all patients must sign a series of consent forms before beginning the cloning process. Both doctors said they have explored all considerations around the debate and are prepared to move forward.

"They are calling us mad scientists. We're not," Zavos said. "If the process is not successful, we will discontinue our efforts."

GRAPHIC: Graphic:
CLONING
One of many possible variations; in this example, the woman from a completely infertile couple is cloned. MotherOs DNA inserted into a donated egg and a surrogate carries the fetus.
Mother
DNA extracted from a cell
Egg donor
DonorOs DNA removed, motherOs DNA inserted
Surrogate mother
Egg implanted
Child Genes identical to motherOs
Source: Encyclopaedia Britannica
/ Knight Ridder Tribune Photo:
Italian doctor Severino Antinori (left) participates in a contentious debate on cloning Tuesday at the National Academy of Sciences in Washington. / RON EDMONDS / Associated Press

LOAD-DATE: August 08, 2001




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