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Copyright 2002 Star Tribune  
Star Tribune (Minneapolis, MN)

June 3, 2002, Monday, Metro Edition

SECTION: NEWS; Pg. 1A

LENGTH: 1353 words

HEADLINE: U.S. Senate to discuss how to keep tabs on a taboo: human cloning;
Medical potential creates division

BYLINE: Sharon Schmickle; Staff Writer

BODY:
In the latest "Star Wars" movie, a bizarre factory creates an army of cloned storm troopers.

     Call something a clone _ at least in the movies _ and it's almost certain to be seen as evil.

     That's the semantic and political reality facing the U.S. Senate this week as it moves toward debates on bills to restrict human cloning.

     Americans overwhelmingly tell pollsters that cloning is taboo. But leave the word cloning out of the description, and they tend to favor some aspects of the research that the Senate is expected to debate.

     "When people hear the word cloning, they think of two Hitlers or two Michael Jordans, and it's scary," said Ellen Murray, who has helped organize hearings on the issue for a subcommittee chaired by Sen. Tom Harkin, D-Iowa.

     Whether the outcome would be another Hitler or the far more pleasant prospect of a second Michael Jordan, there is a consensus in the Senate that such cloning should be banned. The division begins with questions of how far to extend a proposed ban.

     Scientists draw a sharp distinction between cloning to create a person and cloning to create cells that could help cure diabetes, Alzheimer's disease or some other illness.

     The rub is that the first few steps in both procedures are similar. In a process called nuclear transplantation, DNA from a person's cell is transplanted into an egg whose nucleus has been removed. Then the package is stimulated to prompt it to begin dividing and forming an embryo.

     Now begins the difference.

     If the intent were to make a baby, the embryo would be implanted in a uterus and nurtured to grow into a nearly identical genetic copy of the person who donated the original DNA. This is reproductive cloning, which most Americans and most senators are prepared to ban.

     If, instead, the goal was medical therapy, stem cells could be isolated from the early embryo. Such cells have the natural versatility to develop all of the body's specialized tissues _ from heart to skin. Scientists hope to harness that ability to help patients.

     At the University of Wisconsin in Madison, for example, scientists have coaxed human embryonic stem cells to function in mice as brain and spinal-cord cells. The research improves prospects for cell transplants that could repair spinal-cord injuries and reverse the ravages of Parkinson's disease.

     The Wisconsin cells were isolated from embryos created in a fertility clinic, not from clones. If the cells could be created from a patient's body through cloning, the process might reduce chances a cell transplant would be rejected.

     Even though the technology is nowhere near ready for the neighborhood clinic, dozens of groups representing patients who could benefit from the research have joined scientists in lobbying against banning such therapeutic cloning.

     Opponents of the research, including President Bush, are fighting to slam the door on the studies before they go further.

     "Science has set before us decisions of immense consequence," Bush said in urging the Senate to ban all human cloning. "We can pursue medical research with a clear sense of moral purpose or we can travel without an ethical compass into a world we could live to regret. . . . How we answer the question of human cloning will place us on one path or the other."

     The bedrock argument for the opposition is that destroying an embryo is killing a potential person.

     "The key moral issue in research involving cloned embryos is the creation and destruction of a human life," said the Rev. Kevin Fitzgerald of Georgetown University Medical Center when he testified at a Judiciary Committee hearing in February.

Tissue already cloned

     Beyond arguments of when life begins, opponents express revulsion at the notion of growing cells for medical repair work. "Allowing cloning would be taking a significant step toward a society in which human beings are grown for spare body parts," Bush said.

     But scientists already clone human tissue. Tumor cells have been cloned for years in cancer studies. Human DNA routinely is cloned for criminal investigations and for research.

     Many Americans seem less squeamish than cloning foes on Capitol Hill about the scientific use of cloning. In a Gallup Poll conducted in May, 51 percent favored cloning cells from adults for medical use.

     But overall, "the word cloning sets off alarms for Americans," said the Gallup News Service. Gallup found strong opposition to cloning not only humans but also pets and endangered animals. When the pollsters asked about stem-cell studies without using the word cloning, they found stronger support than when they referred to cloning in similar questions.

     The political question before the Senate is whether most voters will make a distinction between types of cloning. All of the several bills that the full Senate is expected to consider in June would ban cloning to create a person.

     Sen. Arlen Specter, R-Pa., is the leading sponsor of a bill that would allow therapeutic cloning and require federal rules to ensure that it is done in a way that protects the rights and safety of people involved.

     Neither Minnesota senator has decided which bill to vote for, but Democrat Paul Wellstone favors this general position, his spokeswoman said Friday.

     Leading the other side is Sen. Sam Brownback, R-Kan., whose bill would ban the creation of a cloned human embryo for any purpose. It proposes criminal penalties of up to 10 years in prison for anyone who participates in any attempt at human cloning and who ships or receives cells or other material taken from a cloned embryo.

     A nearly identical bill passed the House last July.

Dayton undecided

     Sen. Mark Dayton, D-Minn., said he has promised to meet with Brownback and listen to arguments for that bill, but he is keeping his options open.

     "This obviously is very sensitive and highly technical," Dayton said. "I certainly oppose any cloning for reproductive purposes. And I would like to leave a very narrow window for medical and scientific research. So [the question is] where to draw that line. I want to know as much as I can before I decide."

     Because other countries allow cloning for medical uses, scientists have warned that Brownback's bill would make criminals of patients who travel to other countries to receive transplants of cells developed through the research.

     "If a cure or a treatment for Parkinson's disease or Alzheimer's disease were developed in another country using nuclear transplantation, Americans would be alone in being unable to take advantage of that treatment," said Dr. Gerald Fischback, dean of the faculty of medicine at Columbia University in testimony before Harkin's subcommittee.

     Brownback disputes that scenario. The bill leaves plenty of room for scientists to develop therapies using other techniques, he said. "We simply recognize that the creation of cloned human embryos is not a necessary part of the equation," he said.

     With a large block of senators undecided on the issue, neither side was ready to declare victory last week.

    _ Sharon Schmickle is at sschmickle@startribune.com.

More information

     American Association for the Advancement of Science's policy briefing on human cloning:

http://www.aaas.org/spp/cstc/ issues/cloning.htm

     President Bush's statement urging the Senate to ban all forms of human cloning:

http://www.whitehouse.gov/ news/releases/2002/04/ 20020410-4.html

     American Society for Cell Biology's letter signed by 40 Nobel laureates urging the Senate not to ban therapeutic and research cloning: http://www.ascb.org/

publicpolicy/Nobelletter.html

     National Academy of Sciences report, "The Scientific and Medical Aspects of Human Reproductive Cloning": http://www.nap.edu/

catalog/10285.html

     U.S. Conference of Catholic Bishops statement urging the Senate to oppose human cloning for research:

http://www.usccb.org/comm/

archives/2002/02-095.htm



LOAD-DATE: June 3, 2002




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