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FAQs about Cloning, Stem Cell
Research, and ASRM's Position
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What
is Somatic Cell Nuclear Transfer (SCNT) and Therapeutic Cloning for Stem
Cells?
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What
are stem cells and what research is being done on them?
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Which
legislative bill is ASRM endorsing?
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If
cloning research is allowed, isn't ASRM mandating the destruction of
embryos?
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Is
ASRM for stem cell and other kinds of embryo research?
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What
about adult stem cells? Aren't they just as good?
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Where
will the eggs used come from, and won't egg donors be exploited?
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How
many embryos are in freezers already? And are those embryos available
for stem cell research?
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If cloning can be done safely, will ASRM allow it?
1. What is Somatic Cell Nuclear Transfer (SCNT) and
Therapeutic Cloning for Stem Cells?
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This process involves the
nucleus of an egg cell, replacing it with the material from the nucleus
of a "somatic cell" (a skin, heart, nerve or any other non-germ cell),
and stimulating this cell to begin dividing.
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This egg cell is never
fertilized by sperm, and the genetic material within the cell is
virtually identical to the genetic material extracted from the skin or
other cell.
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Once the cells begin dividing
the stem cells can be extracted 5-6 days later.
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By using SCNT, scientists hope
to understand how the protein factors in the egg cell cause these
already specialized somatic cells to become stem cells. Once we
learn how this cell "de-differentiation" occurs, we will no longer need
to use egg cells.
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Because of SCNT, science could
advance to a point where millions of people will have access to life
saving therapies developed using their own DNA.
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When cells, including donated
organs, tissues, or blood, are transplanted or transfused, the
recipient's body mounts a rejection response, attacking these cells as
foreign. SCNT could allow an individual's own cells to be used to
treat or cure that person's disease, without risk of introducing foreign
cells that may be rejected.
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Other methods of developing and
harvesting stem cells may be developed and utilized in the future.
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Somatic cell nuclear transfer
research is an important subset of stem cell research and could allow
researchers to develop stem cell therapies that are specifically
tailored to an individual's medical condition and that do not trigger an
immune rejection response.
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2. What are stem cells and what research is being
done on them?
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Stem cells are special cells
found in very early stage embryos (i.e., 5 days after fertilization of
an egg) and in some types of adult tissue.
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Stem cells are
"undifferentiated" cells (sometimes referred to as "pluripotent"), which
means:
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they have not yet developed
into a particular type of cell that performs a specialized function
(e.g., skin, heart, or nerve cells); and
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they can, under circumstances, develop into many different
types of cells.
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Stem cell research promises to
allow these undifferentiated stem cells to be stimulated to develop into
various types of specialized cells or tissue.
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The molecular processes discovered in working with stem
cells derived from SCNT will be extremely valuable in finding ways to
increase the utility and versatility of adult stem cells.
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3. Which legislative bill is ASRM endorsing?
From ASRM's point of view, all legislative bills currently
being discussed could be improved a little. Currently ASRM feels it
is more important to talk about what should and should not be in a bill.
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4. If cloning research is allowed, isn't ASRM
mandating the destruction of embryos?
That's not the way ASRM sees it. While human embryos
at any stage are worthy of special respect and consideration, most of them
will never be capable of giving rise to a baby. It is not at all
clear that SCNT could ever be used to produce a viable human embryo
capable of developing into a normal human being. We think SCNT can
produce some very special cells, but not yet a child.
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5. Is ASRM for stem cell and other kinds of embryo
research?
YES. ASRM thinks the best way to oversee this
research and the fastest way to develop the science is to bring it under
federal control via NIH funding.
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6. What about adult stem cells? Aren't they
just as good?
It is important that research into possible uses of adult
stem cells continue. But right now it does not appear they will be
as useful as embryonic stem cells.
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7. Where will the eggs used come from, and won't egg
donors be exploited?
Egg donation is already a vital therapy for some infertile
couples. The ASRM and SART have in place strong guidelines on how to
screen, counsel, and compensate potential egg donors. All these
guidelines could be used if seeking donors for stem cell or SCNT purposes
as well as for reproduction. The ASRM is already working with the
FDA to develop regulations on donated reproductive tissues. These
would apply whether these tissues are to be used for reproductive purposes
or for stem cells.
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8. How many embryos are in freezers already? And are
those embryos available for stem cell research?
According to a study
performed by ASRM's affiliate SART- the Society for Assisted Reproductive
Technology and the RAND published in the May 2003 issue of Fertility
and Sterility, there are nearly 400,000 embryos stored in
cryopreservation facilities across the country.
Although this
is a high number, the overwhelming majority of these embryos (88.2%) are
being held to help patients have children in the future. About 4% of
cryopreserved embryos are available for donation. Slightly more than half
of those (about 11,000) are designated for research, while about 9,000 are
slated for donation to help other infertile couples have children. We do
not know how many of the embryos to be donated for research will go to
stem cell research and how many will go to other types of embryo research
projects.
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9. If cloning can be done safely, will ASRM allow
it?
The ASRM has not addressed fully the ethical implications of
cloning.
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